S101

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

• 実験式（ヒル表記法）: C₁₆H₁₇NO₂ · HCl
• CAS番号: 81702-42-3
• 分子量: 291.77
• MDL番号: MFCD00055189
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824192
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 光学活性: [α]22/D +16.1°, c = 1.2 in methanol(lit.)
• 保管条件: desiccated
• 色: off-white to light tan
• 溶解性: 0.1 M HCl: 1.2 mg/mL; ethanol: 3.4 mg/mL; H₂O: 5 mg/mL; aqueous base: unstable
• SMILES記法: Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
• InChI: 1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• InChI Key: YEWHJCLOUYPAOH-PFEQFJNWSA-N

詳細

アプリケーション

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

生物化学的／生理学的作用

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a benzazepine derivative, exhibits anorectic effects.

特徴および利点

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

光に不安定です。

再構成

溶液は、4°Cで数日間は保存することができます。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves