RAB1574

Human Matriptase ELISA

for serum, plasma and cell culture supernatants

• UNSPSCコード: 41116158
• NACRES: NA.32

特性

• 交差性: human
• 包装: kit of 96 wells (12 strips x 8 wells)
• テクニック: ELISA: suitable
• 入力: sample type plasma; sample type cell culture supernatant(s); sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.41 ng/mL; standard curve range: 0.410-100 ng/mL
• 検出方法: colorimetric
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... ST14(6768)

詳細

詳細

The ST14 (suppression of tumorigenicity 14) gene encodes a cell surface serine protease which is also called as matriptase. The ST14 gene is mapped to human chromosome 11q24.3.

This ELISA antibody pair detects Human Matriptase. Other species not yet determined.

アプリケーション

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生物化学的／生理学的作用

St14 (suppression of tumorigenicity 14) forms complexes with serine proteases inhibitors HAIs (hepatocyte growth factor activator inhibitors), to prevent its proteolytic activity. ST14 expression is required for epithelial mesenchymal transition in tumor cells. St14′s biological activity is specific to different substrates, which includes extracellular matrix proteins, hepatocyte growth factor, epidermal growth factor receptor (EGFR), adhesion molecules including Mac25 (insulin-like growth factor-binding protein 7) and Tie2 (angiopoietin-1 receptor) , proteases including urokinase plasminogen activator (uPA), prostasin (PRSS8), matrix metalloprotease 3 (MMP3). Upregulation of the gene is found in progressed epithelial cancer but lower expression of the gene is observed in colon cancer and hence it is termed ‘suppression of tumors′.

その他情報

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Warning
• 危険有害性情報: H290
• 注意書き: P234 - P390
• 危険有害性の分類: Met. Corr. 1
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable