RAB0711

Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

• UNSPSCコード: 41116158
• NACRES: NA.84

特性

• 化学種の反応性: human
• 包装: kit of 96 wells (12 strips x 8 wells)
• テクニック: ELISA: suitable
• assay range: inter-assay cv: <10%; intra-assay cv: <12%
• 検出方法: colorimetric
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... CSF1R(1436)

詳細

詳細

CSF1R (colony stimulating factor 1 receptor) is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

The antibody pair provided in this kit recognizes human Macrophage Colony-stimulating Factor 1 Receptor.

アプリケーション

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

生物化学的／生理学的作用

CSF1R (colony stimulating factor 1 receptor) acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. The protein and its ligand are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

キットの構成要素は別途購入可能です。

• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABWASH4 20X Wash Buffer (Item B)

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Warning
• 危険有害性情報: H290
• 注意書き: P234 - P390
• 危険有害性の分類: Met. Corr. 1
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable