おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to tan
溶解性
DMSO, heptane and xylene: ≥8 mg/mL
保管温度
−20°C
SMILES記法
CCCCCCCCCCCCCCCC(=O)C1=C(O)[C@@H](CO)OC1=O
InChI
1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3/t18-/m1/s1
InChI Key
KZTSLHQKWLYYAC-GOSISDBHSA-N
アプリケーション
RK-682 has been used:
- as a positive control in high-performance liquid chromatography (HPLC)
- as a reference compound in high-performance liqiud chromatography (HPLC)
- as a pan-protein tyrosine phosphatase non-receptor type (PTPN) inhibitor to study its effects on the activated lymphocytes
生物化学的／生理学的作用
RK-682は、プロテインチロシンホスファターゼの非競合阻害剤であり、CD45とVHRの脱リン酸化活性を、それぞれのIC50値54 μMおよび2.0 μMで阻害し、PTP1Bに対しては4.5 μMで作用します。
プロテインチロシンホスファターゼ特異的非競合阻害剤
特徴および利点
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
R2033-BULK:
R2033-1MG:
R2033-VAR:
R2033-200UG:
最新バージョンのいずれかを選択してください：
Yunkun Liu et al.
mBio, 6(6), e01714-e01715 (2015-11-12)
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, an RNA-guided nuclease for specific genome editing in vivo, has been adopted in a wide variety of organisms. In contrast, the in vitro application of the CRISPR/Cas9 system
Akiko Fujimura et al.
Cancer immunology, immunotherapy : CII, 68(10), 1649-1660 (2019-09-29)
It has been shown that protein tyrosine phosphatase non-receptor type (PTPN) 3 inhibits T-cell activation. However, there is no definitive conclusion about how the inhibition of PTPN3 in lymphocytes affects immune functions in human lymphocytes. In the present study, we
Yousof Tahtah et al.
Fitoterapia, 110, 52-58 (2016-02-18)
Type 2 diabetes (T2D) constituted 90% of the global 387 million diabetes cases in 2014. The enzyme protein-tyrosine phosphatase 1B (PTP1B) has been recognized as a therapeutic target for treatment of T2D and its adverse complications. With the aim of
Rosa Martha Perez Gutierrez et al.
Journal of Asian natural products research, 22(7), 603-617 (2019-07-20)
This present study was to evaluate the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of nine diterpenes isolated from seeds of Phalaris canariensis, as well as their effect on streptozotocin-nicotinamide-induced type 2 diabetic mice. Their structures were established by spectroscopic
資料
Sigma-Aldrich offers many products related to phosphoprotein phosphatases (Tyrosine) for your research needs.
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