PLA0259

Rabbit anti-RuvBL2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• 別名: 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, 51-KD, CGI-46, ECP-51, ECP51, INO80 complex subunit J, INO80J, RVB2, Reptin 52, Reptin52, RuvB (E coli homolog)-like 2, RuvB-like 2 (E. coli), TAP54-beta, TIH2, TIP48, TIP49b, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, repressing pontin 52, reptin, reptin52 protein
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• グレード: Powered by Bethyl Laboratories, Inc.
• 交差性: human, mouse
• テクニック: immunohistochemistry: 1:500- 1:2,000; immunoprecipitation (IP): 5-15 μg/mg; western blot: 1:2,000- 1:10,000
• アクセッション番号: NP_006657.1
• UniProtアクセッション番号: Q9Y230
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rabbit ... RuvBL2(10856)

詳細

詳細

RuvB-like 2 (RUVBL2), a transcription factor, belongs to the AAA+ protein subfamily of conserved ATPases linked with diverse cellular functions. A distinctive domain II (DII) protrudes from one side of the hexamer and defines two separate faces of the ring in RUVBL2.

免疫原

The epitope recognized by PLA0259 maps to a region between residue 1 and 50 of human RuvB-like 2 using the numbering given in entry NP_006657.1 (GeneID 10856).

生物化学的／生理学的作用

RuvB-like 2 (RUVBL2) plays a regulatory role in the Fanconia anemia (FA) pathway, the assembly of the telomerase holoenzyme, and nonsense-mediated mRNA decay (NMD). It may play a role in tumorigenesis and cancer progression. Overexpression of the RUVBL2 protein is observed in hepatocellular carcinoma (HCC), renal cell carcinoma, colorectal cancer, gastric cancer, breast cancer, and salivary gland cancer. It can be used as a promising target for preventing and treating HCC.

物理的形状

トリスクエン酸／リン酸塩緩衝液、pH 7～8、0.09％ アジ化ナトリウム含有

その他情報

RuvB-like 2 (RuvBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities [taken from NCBI Entrez Gene (GeneID: 9400)].

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable