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Merck
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主要文書

安全性情報

PLA0132

Sigma-Aldrich

Rabbit anti-Sirt1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

別名:

SIR2, SIR2-like protein 1, SIR2L1, SIR2alpha, hSIR2, hSIRT1, homolog) 1, regulatory protein SIR2 homolog 1, sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), sirtuin (silent mating type information regulation 2; S. cerevisiae, sirtuin type 1

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

affinity purified immunoglobulin

抗体製品タイプ

primary antibodies

グレード

Powered by Bethyl Laboratories, Inc.

化学種の反応性

human

テクニック

immunoprecipitation (IP): 1-4 μg/mg
western blot: 1:2,000- 1:10,000

アクセッション番号

NP_036370.2

UniProtアクセッション番号

Q96EB6

輸送温度

wet ice

保管温度

2-8°C

遺伝子情報

rabbit ... Sirt1(23411)

免疫原

The epitope recognized by PLA0132 maps to a region between residue 700 and the C-terminus (residue 747) of human Silent Mating Type Information Regulation 2 homolog 1 using the numbering given in entry NP_036370.2 (GeneID 23411).

物理的形状

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

その他情報

Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD÷-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

12 - Non Combustible Liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

PLA0132-100UL-KC:
PLA0132-100UL:

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Hongyi Zhang et al.
International journal of oncology, 45(5), 2143-2152 (2014-08-15)
MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether
Liang Lv et al.
Medical oncology (Northwood, London, England), 31(6), 965-965 (2014-05-13)
Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins. However, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. SIRT1 protein
H J Bae et al.
Oncogene, 33(20), 2557-2567 (2013-06-04)
Mammalian sirtuin 1 (SIRT1) has connected to an ever widening circle of activities that encompass cellular stress resistance, energy metabolism and tumorigenesis. However, underlying mechanisms leading to oncogenic SIRT1 overexpression are less understood. In this study, we identified SIRT1 regulatory
Wei Xu et al.
Shock (Augusta, Ga.), 42(5), 440-447 (2014-07-09)
High-mobility group protein box 1 (HMGB1) is essential in the response to injury during sepsis. We hypothesized that resveratrol (RESV) administration would inhibit nuclear-cytoplasmic HMGB1 translocation in hepatocytes, which is associated with sirtuin 1 (SIRT1) upregulation. We investigated the regulatory
Thomas K Sin et al.
The Journal of physiology, 592(12), 2535-2548 (2014-03-19)
Elevations of cardiomyocyte apoptosis and fibrotic deposition are major characteristics of the ageing heart. Resveratrol, a polyphenol in grapes and red wine, is known to improve insulin resistance and increase mitochondrial biogenesis through the SIRT1-PGC-1α signalling axis. Recent studies attempted
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