N9150

Nystatin

ready made solution, suitable for cell culture

• 別名: フンギシジン, マイコスタチン
• CAS番号: 1400-61-9
• MDL番号: MFCD25541651
• UNSPSCコード: 12352207
• NACRES: NA.76

特性

• product name: ナイスタチン, suitable for cell culture
• 由来生物: Streptomyces noursei
• 形状: solution
• テクニック: cell culture | mammalian: suitable
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O
• InChI: 1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChI Key: VQOXZBDYSJBXMA-QEKUPDCNSA-N

詳細

詳細

Nystatin is a fungistatic and fungicidal polyene antibiotic. It binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

生物化学的／生理学的作用

作用機序：ナイスタチンは真菌の細胞膜内のエルゴステロールに結合し、膜の透過性を増大させ、ナイスタチン／エルゴステロールに基づくイオンチャネルを生成することにより作用します。 また、脂質ラフト阻害試薬および膜関連コレステロールとしても機能します。

抗菌スペクトル：ナイスタチンは真菌、酵母およびカビに作用します。

特徴および利点

• Nystatin ready made solution is a fully solubilized formulation of Nystatin with potency of 8000-13000 units/ml according to USP standard.
• Nystatin ready made solution is 0.2μm filtered, endotoxin.
• The suggested working concentration of Nystatin ready made solution is 30 units/ml.
• The ready made solution is light sensitive. It is recommended to store the solution in the dark.
• It is recommended to avoid freeze thaw cycles of this product. Therefore, it is recommended to aliquot and store at -20°C.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable