リコンビナント
expressed in baculovirus infected Sf9 cells
品質水準
製品種目
PRECISIO® Kinase
アッセイ
≥70% (SDS-PAGE)
フォーム
buffered aqueous glycerol solution
比活性
47-63 nmol/min·mg
分子量
~130 kDa
UniProtアクセッション番号
関連疾患
cancer
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... PAK7(57144)
生物化学的／生理学的作用
PAK7 (p21 protein (Cdc42/Rac)-activated kinase 7) belongs to the group-2 PAKs and can activate JNK (Jun N-terminus kinase). It contain an amino-terminal CDC42 (cell division cycle 42)/RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1) interactive domain and a carboxyl terminal kinase domain. It plays an important role in outgrowth of neuron cells and synaptic vesicle trafficking. In mice, absence of PAK7 and PAK6 causes learning and locomotion defects. It is mainly expressed in brain. However, it is also considered as an oncogene because of its expression in colorectal, esophageal and gastric cancers.
物理的形状
50 mM Tris-HCl溶液(pH 7.5、150 mM NaCl、0.25 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF、25%グリセロール含有)。
法的情報
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
カルタヘナ法
カルタヘナ法
Jan Code
K3268-10UG-PW:
K3268-BULK:
K3268-10UG:
K3268-VAR:
最新バージョンのいずれかを選択してください：
Diyou Li et al.
Molecular and cellular biochemistry, 383(1-2), 191-199 (2013-07-24)
P21-activated kinase 5 (PAK5) is the recently identified member of the group II p21-activated kinases (PAKs) family, which is characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding domain and a carboxyl terminal kinase domain. However, the role of PAK5
Shun He et al.
PloS one, 9(12), e113989-e113989 (2014-12-02)
Aurora-A overexpression is common in various types of cancers and has been shown to be involved in tumorigenesis through different signaling pathways, yet how the deregulation affects cancer therapeutics remains elusive. Here we showed that overexpression of Aurora-A rendered esophageal
Akhilesh Pandey et al.
Oncogene, 21(24), 3939-3948 (2002-05-29)
The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the
Kun Han et al.
Cell biology international, 38(12), 1394-1402 (2014-07-24)
p21-activated kinase 7 (PAK7), also named as PAK5, is a member of Rac/Cdc42-associated Ser/Thr protein kinases. It is overexpressed in some types of cancer such as colorectal and pancreatic cancers. However, the expression status and biological function of PAK7 in
Zahara M Jaffer et al.
The international journal of biochemistry & cell biology, 34(7), 713-717 (2002-04-16)
The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into
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