K0890

Anti-Potassium Channel K_V11.3 (erg3) ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: Anti-KCNH7, Anti-ether-a-go-go-related channel 3
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: lyophilized powder
• 化学種の反応性: mouse, human, rat
• テクニック: immunohistochemistry: suitable using rat brain sections; western blot: 1:300 using rat brain lysates
• UniProtアクセッション番号: Q9NS40
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KCNH7(90134) ; mouse ... Kcnh7(170738) ; rat ... Kcnh7(170739)

詳細

詳細

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K⁺ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.

特異性

The K_V11.3 antibody is directed against an intracellular epitope of C-terminal part of K_V11.3.

免疫原

synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat K_V11.3.

生物化学的／生理学的作用

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K⁺ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.

物理的形状

Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.

再構成

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

安全性情報

• 保管分類コード: 10 - Combustible liquids