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由来生物
rat
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
37895, monoclonal
形状
lyophilized powder
化学種の反応性
mouse
テクニック
flow cytometry: suitable
neutralization: suitable
western blot: suitable
アイソタイプ
IgG2a
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
mouse ... Ifng(15978)
詳細
Interferon-γ (IFN-γ) belongs to Type II class of interferons and is produced by T helper cells (specifically, Th1 cells), natural killer (NK) and natural killer T (NKT) cells and cytotoxic T cells (TC cells) . It has various biological functions including antiviral activity like inhibition of cell or tumor growth, act as a potent modulator of immune responses and modifies cellular processes as well as stimulates the differentiation of B cells into immunoglobulin-producing cells. Monoclonal Anti-Interferon-γ antibody can be used in immunoblotting. Rat anti-Interferon-γ antibody has shown no cross-reactivity for recombinant human IFN-γ or recombinant rat IFN-γ.
特異性
The antibody does not cross-react with recombinat human IFN-γ or recombinant rat IFN-γ.
免疫原
recombinant mouse IFN-γ.
アプリケーション
Monoclonal Anti-Interferon-γ antibody can be used in neutralization and indirect ELISA.
物理的形状
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline and 5% trehalose.
調製ノート
Purified from cell culture supernatant using protein G.
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保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I1142-VAR:
I1142-.5MG-PW:
I1142-BULK:
I1142-.5MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
J Vilcek et al.
Journal of immunology (Baltimore, Md. : 1950), 135(3), 1851-1856 (1985-09-01)
Interferon (IFN)-gamma production, stimulated by the addition of exogenous interleukin (IL) 2, T cell mitogens, or tuberculin purified protein derivative (PPD) was studied in cultures of separated human mononuclear cells or unseparated peripheral blood leukocytes (PBL). IFN-gamma was induced by
P B Fisher et al.
Pharmacology & therapeutics, 27(2), 143-166 (1985-01-01)
As described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (Table 2). Depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation.
I Gresser et al.
Proceedings of the National Academy of Sciences of the United States of America, 66(4), 1052-1058 (1970-08-01)
Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210
P D Benech et al.
The Journal of experimental medicine, 176(4), 1115-1123 (1992-10-01)
The human Fc gamma RI (CD64) is a high affinity receptor for the Fc portion of immunoglobulin (Ig), and its constitutively low expression on the cell surface of monocyte/macrophage and neutrophils is selectively upregulated by interferon gamma (IFN-gamma) treatment (Perussia
Jamie R Schoenborn et al.
Advances in immunology, 96, 41-101 (2007-11-06)
Interferon-gamma (IFN-gamma) is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number of autoinflammatory and autoimmune diseases. This cytokine is produced predominantly by natural killer (NK) and natural killer
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