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Key Documents

安全性情報

HPA043420

Sigma-Aldrich

抗UMOD抗体 ウサギ宿主抗体

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

別名:

Anti-ADMCKD2, Anti-ADTKD1, Anti-FJHN, Anti-HNFJ, Anti-HNFJ1, Anti-MCKD2, Anti-THGP, Anti-THP

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About This Item

UNSPSCコード:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

製品種目

Prestige Antibodies® Powered by Atlas Antibodies

形状

buffered aqueous glycerol solution

化学種の反応性

human

強化検証

orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation

テクニック

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:1000-1:2500

免疫原配列

GYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGK

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... UMOD(7369)

詳細

Uromodulin (UMOD) is a glycoprotein produced particularly in renal tubular cells and released into urine. The gene is located on human chromosome 16p12.3. It is the most abundant protein in urine.

免疫原

uromodulin

アプリケーション

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生物化学的/生理学的作用

Uromodulin (UMOD) plays an important role in inflammatory responses and acts as a potential therapeutic for hypertension. It provides innate immunity and protects from kidney stones. The protein provides protection from uropathogenic bacteria. Mutations in this gene is associated with inflammation and development of kidney diseases, such as medullary cystic kidney disease 2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) and familial juvenile hyperuricemic nephropathy (FJHN).

特徴および利点

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST82316

物理的形状

PBS溶液(pH 7.2、40%グリセロール、0.02% アジ化ナトリウム含有)

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 1


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

HPA043420-25UL:
HPA043420-100UL:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

A structured interdomain linker directs self-polymerization of human uromodulin
Bokhove M, et al.
Proceedings of the National Academy of Sciences of the USA, 113(6), 1552-1557 (2016)
Uromodulin rs4293393 T> C variation is associated with kidney disease in patients with type 2 diabetes
Kumar V, et al.
The Indian Journal of Medical Research, 146(2), S15-S15 (2017)
Unravelling the genetic basis of renal diseases; from single gene to multifactorial disorders
Kumar V, et al.
The Journal of Pathology, 146(Suppl 2), S15-S15 (2017)
Modulation of urinary peptidome in humans exposed to high altitude hypoxia
Mainini V, et al.
Molecular Biosystems, 8(4), 959-966 (2012)
Functional analysis of UMOD gene and its effect on inflammatory cytokines in serum of essential hypertension patients
Jian L, et al.
International Journal of Clinical and Experimental Pathology, 8(9), 11356-11356 (2015)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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