HPA019711

抗LANCL2抗体 ウサギ宿主抗体

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-LanC-like protein 2, Anti-Testis-specific adriamycin^® sensitivity protein
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA019711
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:50-1:200
• 免疫原配列: ALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDY
• UniProtアクセッション番号: Q9NS86
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LANCL2(55915)

詳細

詳細

LANCL2 (LanC lantibiotic synthetase component C-like 2) is a highly conserved plasma membrane associated protein belonging to the eukaryotic lanthionine synthetase component C-like (LANCL) protein family. It is located on chromosome 7 and localized to the plasma membrane, juxta-nuclear vesicles, and the nucleus. It is widely distributed protein in several human tissues such as brain and in testis. It consists of 15 cysteine residues, N-terminal PIP-binding motif with the polybasic region KRLKLH.

免疫原

LanC様タンパク質2のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

LANCL2 (LanC lantibiotic synthetase component C-like 2) plays a crucial role in the membrane association and in cortical cytoskeleton organization. During membrane restructuring, its N-terminal putative myristoylation site directly interacts with PI (phosphatidylinositol) monophosphates. It also plays an important role in the membrane association and cellular sensitivity to the anticancer drug Adriamycin through myristoylation. It has been reported that LANCL2 overexpression enhances cell detachment upon cholesterol depletion. LANCL2 is involved in the ABA (Abscisic Acid) signaling pathway. It helps ABA to bind on the membrane of human granulocytes.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST74971

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable