HPA014667
Anti-DPM3 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
別名:
Anti-DPM synthase complex subunit 3, Anti-Dolichol-phosphate mannose synthase subunit 3, Anti-Dolichol-phosphate mannosyltransferase subunit 3, Anti-Dolichyl-phosphate beta-D-mannosyltransferase subunit 3, Anti-MPD synthase subunit 3, Anti-Mannose-P-dolichol synthase subunit 3
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About This Item
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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
製品種目
Prestige Antibodies® Powered by Atlas Antibodies
形状
buffered aqueous glycerol solution
化学種の反応性
human
強化検証
recombinant expression
Learn more about Antibody Enhanced Validation
テクニック
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:20-1:50
免疫原配列
FHDCEDAARELQSQIQEARADLARR
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... DPM3(54344)
詳細
DPM3 (dolichyl-phosphate mannosyltransferase polypeptide 3) is a component of dolichol-P-mannose (Dol-P-Man or DPM) synthase complex, which also includes DPM1 and DPM2. It is a transmembrane protein, which resides in the endoplasmic reticulum (ER). It has two alternatively spliced isoforms, which differ in the length of their N-termini. Its transmembrane region is present in the N-terminal, and the C-terminal is hydrophilic in nature, and binds to DPM1. It is composed of 92 amino acids, and has a coiled-coil domain in its C-terminal.
免疫原
ドリコールリン酸マンノシルトランスフェラーゼサブユニット3のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。
アプリケーション
Prestige抗体®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。
生物化学的／生理学的作用
DPM3 (dolichyl-phosphate mannosyltransferase polypeptide 3) anchors the cytosolic catalytic subunit DPM1 to the endoplasmic reticulum (ER) membrane, in the DPM complex. This complex catalyzes the conversion of GDP-mannose and dolichol-phosphate to dolichol-P-mannose. Mutation in this gene, in one female patient, was found to be linked to congenital disorders of glycosylation (CDG) type I, characterized by mild muscular dystrophy, dilated cardiomyopathy and increased levels of transaminases. Its expression is regulated by PLC (phospholipase C)γ, and it responds to androgen in non-invasive prostate cancer cells. It suppresses prostate cancer invasiveness, and promotes cell apoptosis. It might also be involved in maintaining normal cell-extracellular matrix (ECM) interactions, by regulating the normal expression of GPI-linked cell surface proteins. Mutations in this gene result in α-dystroglycanopathy, and thus, this protein acts as a link between α-dystroglycanopathy and CDG.
特徴および利点
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
関連事項
Corresponding Antigen APREST72976
物理的形状
PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。
法的情報
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
HPA014667-100UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Dirk J Lefeber et al.
American journal of human genetics, 85(1), 76-86 (2009-07-07)
Alpha-dystroglycanopathies such as Walker Warburg syndrome represent an important subgroup of the muscular dystrophies that have been related to defective O-mannosylation of alpha-dystroglycan. In many patients, the underlying genetic etiology remains unsolved. Isolated muscular dystrophy has not been described in
Amy C Yang et al.
Molecular genetics and metabolism, 110(3), 345-351 (2013-07-17)
Congenital disorders of glycosylation (CDG) are rare genetic defects mainly in the post-translational modification of proteins via attachment of carbohydrate chains. We describe an infant with the phenotype of a congenital muscular dystrophy, with borderline microcephaly, hypotonia, camptodactyly, severe motor
E J Manos et al.
Oncogene, 20(22), 2781-2790 (2001-06-23)
The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray expression
Hisashi Ashida et al.
The Journal of biological chemistry, 281(2), 896-904 (2005-11-11)
Dolichol-phosphate mannose (DPM) synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. We previously identified DPM3, the third component of this enzyme, which was co-purified with DPM1 and DPM2. Here, we have established
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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