おすすめの製品
由来生物
chicken
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human
メーカー／製品名
Genway 15-288-20089F
テクニック
indirect ELISA: suitable
western blot: suitable
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... APOB(338)
免疫原
ヒトLDL未変性タンパク質。
アプリケーション
Anti-LDL antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生物化学的／生理学的作用
The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein encoded by the LDLR gene in humans and belongs to the Low density lipoprotein receptor gene family. It is located on chromosome number 19. LDL receptor is a mosaic protein constituiting of exons shared with different proteins. It is crucial for cholesterol homeostasis and deficiency in LDLR functions leads to hypercholesterolemia. LDLR is a type I transmembrane protein that needs O-glycosylation for stable expression at the cell surface. Mutation in this gene may cause familial hypercholesterolemia (FH), which is an autosomal dominant disease.
物理的形状
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
GW20089F-VAR:
GW20089F-BULK:
GW20089F-50UG:
最新バージョンのいずれかを選択してください：
Nis Borbye Pedersen et al.
The Journal of biological chemistry, 289(25), 17312-17324 (2014-05-07)
The low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis and deficiency in LDLR functions cause hypercholesterolemia. LDLR is a type I transmembrane protein that requires O-glycosylation for stable expression at the cell surface. It has previously been suggested
Isabel De Castro-Orós et al.
BMC medical genomics, 7, 17-17 (2014-04-09)
GWAS have consistently revealed that LDLR locus variability influences LDL-cholesterol in general population. Severe LDLR mutations are responsible for familial hypercholesterolemia (FH). However, most primary hypercholesterolemias are polygenic diseases. Although Cis-regulatory regions might be the cause of LDL-cholesterol variability; an
Paulo Caleb Junior Lima Santos et al.
Atherosclerosis, 233(1), 206-210 (2014-02-18)
Familial hypercholesterolemia (FH) is an autosomal dominant disease caused mainly by LDLR mutations. This study assessed the influence of the presence and type of LDLR mutation on lipid profile and the response to lipid-lowering therapy in Brazilian patients with heterozygous
T C Südhof et al.
Science (New York, N.Y.), 228(4701), 815-822 (1985-05-17)
The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of
U Francke et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(9), 2826-2830 (1984-05-01)
The availability of a species-specific monoclonal antibody that recognizes the low density lipoprotein (LDL) receptor of human but not hamster origin permitted assignment of the structural gene for the human receptor to chromosome 19. The antibody was used to detect
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