おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
lyophilized powder
化学種の反応性
rat
テクニック
immunohistochemistry: 1:200 using Rat brain frozen sections
western blot: 1:200-1:300 using Rat brain membranes
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... GABRA3(2556)
mouse ... Gabra3(14396)
rat ... Gabra3(24947)
詳細
GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.
免疫原
ヒトGABA(A)レセプタ-α3サブユニットのアミノ酸残基1-15に相当するペプチド。マウス、ラットと同一です。ウシで高度に保存されています(14/15残基)。
アプリケーション
Anti-GABAA Receptor (α3 subunit) antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:200 using rat brain frozen sections and immunoblotting at 1:200-1:300 using rat brain membranes.
生物化学的／生理学的作用
The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α3 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.
物理的形状
凍結乾燥品 (PBS, pH 7.4, 1%BSA, 5%スクロ-ス, 0.025%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Eung-Kwon Pae et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 29(8), 819-826 (2011-10-04)
Perinatal hypoxia commonly causes brain injury in infants, but the time course and mechanisms underlying the preferential male injury are unclear. Intermittent hypoxia disturbs cerebellar γ-aminobutyric (GABA)-A receptor profiles during the perinatal period, possibly responding to transient excitatory processes associated
B Gao et al.
Neuroscience, 54(4), 881-892 (1993-06-01)
GABAA-receptors in the brain display a striking structural heterogeneity, which is based on a multiplicity of diverse subunits. The allocation of GABAA-receptor subtypes to identified neurons is essential for an analysis of the functional significance of receptor heterogeneity. Among GABA-receptive
Shubhash C Yadav et al.
Frontiers in molecular neuroscience, 12, 99-99 (2019-05-09)
In the mammalian retina, amacrine cells represent the most diverse cell class and are involved in the spatio-temporal processing of visual signals in the inner plexiform layer. They are connected to bipolar, other amacrine and ganglion cells, forming complex networks
Manmei Long et al.
Molecular cancer, 16(1), 167-167 (2017-10-29)
MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic cancer (PC). Our previous study demonstrated that Gabra3 plays critical roles in cancer
Keita Harada et al.
Journal of neurochemistry, 158(2), 153-168 (2021-03-12)
γ-Aminobutyric acid (GABA) is thought to play a paracrine role in adrenal medullary chromaffin (AMC) cells. Comparative physiological and immunocytochemical approaches were used to address the issue of how the paracrine function of GABA in AMC cells is established. GABAA
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