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由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
≥97% (SDS-PAGE)
フォーム
lyophilized powder
有効性
1.0-4.0 ng/mL
分子量
~7.9 kDa
包装
pkg of 10 μg
保管条件
avoid repeated freeze/thaw cycles
テクニック
cell culture | mammalian: suitable
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... CXCL1(2919)
詳細
GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), is a member of the small soluble chemokine protein family. It belongs to the C-X-C subfamily, which is comprised of 17 members. It contains a conserved glutamic acid-leucine-arginine (ELR) domain. This protein is expressed on stromal cells such as, endothelial cells, fibroblasts and blood-circulating cells.
生物化学的／生理学的作用
GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), plays an essential role in neutrophil recruitment, and the initiation of angiogenesis. This gene is up-regulated in multiple cancer types such as, gastric cancer, renal cell carcinoma, prostate cancer and melanoma. The expression of this protein is also elevated in HER2 positive metastatic breast cancer. Its expression is increased in fibroblasts, which might be involved in breast tumor progression, and its stromal expression in breast cancer is linked to poor prognosis. This gene is also up-regulated in the aggressive phenotype of bladder cancer. Polymorphism rs4074 A in this gene is also associated with susceptibility to alcoholic cirrhosis.
物理的形状
凍結乾燥品(25%アセトニトリル、0.1%トリフルオロ酢酸溶液、サイトカイン1 μgあたりBSA 50 μg含有、0.2 μmフィルター滅菌済み)。
アナリシスノート
生物学的活性は、hCXCR2をトランスフェクションしたマウスBaF/3細胞の走化性誘導活性によって測定しています。
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
保管分類コード
3 - Flammable liquids
WGK
WGK 2
引火点(°F)
35.6 °F - (Acetonitrile)
引火点(℃)
2.0 °C - (Acetonitrile)
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
最新バージョンのいずれかを選択してください：
An Zou et al.
BMC cancer, 14, 781-781 (2014-10-26)
CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of CXCL1 expression in breast cancer has not been fully characterized. Fibroblasts are important cellular components of the breast tumor microenvironment, and recent
Hans Dieter Nischalke et al.
PloS one, 8(11), e80848-e80848 (2013-11-22)
CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on
Makito Miyake et al.
BMC cancer, 13, 322-322 (2013-07-03)
Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, colon and skin cancers, but limited studies to date have described CXCL1 protein expression
J M Schröder et al.
Journal of immunology (Baltimore, Md. : 1950), 139(10), 3474-3483 (1987-11-15)
A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC. Biologic activities of the purified cytokine
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