E8031

エスモロール 塩酸塩

≥98% (HPLC), solid

• 別名: 塩酸4-[2-ヒドロキシ-3-[(1-メチルエチル)アミノ]プロポキシ]ベンゼンプロパン酸メチルエステル 塩酸塩
• 実験式（ヒル表記法）: C₁₆H₂₆NClO₄
• CAS番号: 81161-17-3
• 分子量: 331.83
• MDL番号: MFCD00941432
• UNSPSCコード: 12352200
• PubChem Substance ID: 329799075
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: desiccated
• mp: 89.0-90.6 °C
• 溶解性: H₂O: 12 mg/mL
• オーガナイザー: Baxter
• 保管温度: 2-8°C
• SMILES記法: Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
• InChI: 1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H
• InChI Key: GEKNCWBANDDJJL-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRB1(153) , ADRB2(154)

詳細

アプリケーション

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

生物化学的／生理学的作用

塩酸エスモロ-ルは超短時間作用型のβ₁アドレナリン受容体アンタゴニストです(β₁受容体占拠率=84.7%)。

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.

特徴および利点

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves