D3775

ドキシラミン コハク酸塩

• 実験式（ヒル表記法）: C₁₇H₂₂N₂O · C₄H₆O₄
• CAS番号: 562-10-7
• 分子量: 388.46
• EC Number: 209-228-7
• MDL番号: MFCD00056168
• UNSPSCコード: 12352116
• PubChem Substance ID: 24278368
• NACRES: NA.77

特性

• 形状: powder
• 品質水準: 200
• オーガナイザー: Sanofi Aventis
• SMILES記法: OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
• InChI: 1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
• InChI Key: KBAUFVUYFNWQFM-UHFFFAOYSA-N
• 遺伝子情報: human ... HRH1(3269)

詳細

詳細

Doxylamine belongs to the ethanolaime class of antihistamines and is metabolized by the liver into N-demethyl doxylamine and N,N-didemethyl doxylamine. It is generally available as an over the counter (OTC) drug for allergy and cold symptoms.

アプリケーション

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Doxylamine succinate salt has been used to study the effects of non-teratogenic exposures on morphology and gene expression in human embryonic stem cell aggregates (HESCA)-CSR, under low concentration of retinoic acid in CS medium.

生物化学的／生理学的作用

H₁ヒスタミンレセプタ-アンタゴニストであり、睡眠薬です。

特徴および利点

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332,H335
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves