D1413

2′,3′-ジデヒドロ-3′-デオキシチミジン

≥98% (TLC)

• 別名: 1-(2,3-ジデオキシ-β-D-グリセロ-ペント-2-エノフラノシル)チミン, 2′,3′-アンヒドロチミジン, d4T, スタブジン
• 実験式（ヒル表記法）: C₁₀H₁₂N₂O₄
• CAS番号: 3056-17-5
• 分子量: 224.21
• MDL番号: MFCD00132921
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278356
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98% (TLC)
• フォーム: powder
• 保管温度: −20°C
• SMILES記法: CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
• InChI: 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
• InChI Key: XNKLLVCARDGLGL-JGVFFNPUSA-N

詳細

詳細

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

アプリケーション

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

生物化学的／生理学的作用

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)