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Merck

C6995

Sigma-Aldrich

Anti-COMT (N-terminal) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

別名:

抗カテコール-O-メチルトランスフェラーゼ抗体

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

IgG fraction of antiserum

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen ~24 kDa (and ~28 kDa)

交差性

human, rat, mouse

テクニック

western blot: 1:250-1:500 using whole extracts of mouse and rat liver and HEK-293T cells expressing human COMT

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... COMT(1312)
mouse ... Comt1(12846)
rat ... Comt(24267)

詳細

The gene Catechol-O-methyltransferase (COMT) is mapped to human chromosome 22q11.2. COMT is also referred to as HEL-S-98n. It is widely expressed in various tissues, including brain, liver, kidney, endometrium and breast.

特異性

The antibody recognizes MB-COMT and S-COMT.

アプリケーション

Anti-COMT (N-terminal) antibody produced in rabbit has been used in immunoblotting.

生物化学的/生理学的作用

Catechol-O-methyltransferase (COMT) is a Mg2+-dependent enzyme. COMT catalyzes transfer of methyl groups from S-adenosyl methionine to catecholamines. It is responsible for degradation of catecholamines and thereby results in psychiatric disorders and symptoms. Met/Met genotype individuals can acquire skill in executive function tasks (as multi-unmanned vehicles supervisory control, to a higher level and/or faster than other genotype groups). On the other hand, COMT polymorphism is linked to major depressive disorder and bipolar disorder. The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children. COMT polymorphism is associated with high risk of premature ovarian insufficiency. COMT single nucleotide polymorphism preoperative humans psychological status and postoperative opioid analgesia efficacy. COMT acts as a tumor supressor gene for colorectal cancer cell lines. Overexpression of COMT supresses pancreatic cancer.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

C6995-25UL:
C6995-200UL:
IXO14775:
C6995-VAR:
C6995-BULK:


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試験成績書(COA)

Lot/Batch Number

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文書ライブラリにアクセスする

Emerson Barchi Cordts et al.
Journal of ovarian research, 7, 47-47 (2014-05-09)
Estrogens are important factors in the female reproductive functions and are processed by a number of enzymes along their metabolic pathway. The COMT gene constitutes a crucial element in estrogen metabolism and is assumed to be involved in the development
Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
Maasz G, et al.
Disease models & mechanisms, 10(2), 127-139 (2017)
A L Potapov et al.
Anesteziologiia i reanimatologiia, 60(3), 48-51 (2015-09-30)
To evaluate the influence of µl-opioid receptor (OPRM1) 118A>G and catechol-O-methyltransferase (COMT) 1947G>A gene single nucleotide polymorphisms (SNP) combinations on postoperative opioid analgesia (POA) efficacy. In 100 consecutive patients scheduled for major urologic surgeries the SNPs of OPRM1 118A>G and
G Pandolfo et al.
Journal of affective disorders, 177, 108-113 (2015-03-15)
Major depressive disorder (MDD) and bipolar disorder (BD) are the two most common mood disorders. Given the recognized involvement of catecholamines in depression, genetic research focused on the evaluation of polymorphisms in genes coding for proteins that regulate neurotransmitter release
Wenming Wu et al.
Archives of medical research, 46(1), 17-23 (2014-12-24)
Catechol-O-methyltransferase (COMT) has been reported as an important molecule in various types of cancers. The biological function of COMT in colorectal cancer (CRC) has not yet been fully investigated. We constructed a transient transfection of a CRC cell lines to

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