C5776

コカイン 塩酸塩

• 別名: エクゴニンメチルエステルベンゾアート 塩酸塩
• 実験式（ヒル表記法）: C₁₇H₂₁NO₄ · HCl
• CAS番号: 53-21-4
• 分子量: 339.81
• EC Number: 200-167-1
• MDL番号: MFCD00058119
• UNSPSCコード: 12352200
• PubChem Substance ID: 329775099
• NACRES: NA.77

特性

• フォーム: powder
• 品質水準: 200
• 薬剤管理: USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• アプリケーション: forensics and toxicology
• SMILES記法: Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
• InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
• InChI Key: PIQVDUKEQYOJNR-VZXSFKIWSA-N

詳細

アプリケーション

Cocaine hydrochloride has been used:

• in saline control to study the effects of cocaine self-administration in mouse brain
• as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)
• to examine conditioning to intravenous cocaine hydrochloride

生物化学的／生理学的作用

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Inhibits the dopamine, norepinephrine, and serotonin transporters.

特徴および利点

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H300 + H330,H336,H361d
• 注意書き: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• 危険有害性の分類: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges