C4249

Cystatin B human

recombinant, expressed in E. coli, solid, ≥95% (SDS-PAGE)

• 別名: CPI-B, CST6, CSTB, EPM1, Liver Thiol Proteinase Inhibitor, PME, STFB, Stefin B
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• product name: Cystatin B human, recombinant, expressed in E. coli
• リコンビナント: expressed in E. coli
• 品質水準: 200
• 詳細: contains a N-terminal 7X His-tag
• アッセイ: ≥95% (SDS-PAGE)
• 形状: solid
• 分子量: apparent mol wt ~13 kDa by SDS-PAGE (reducing)
• NCBIアクセッション番号: NP_000091
• 保管温度: −20°C
• 遺伝子情報: human ... CSTB(1476)

詳細

詳細

Cystatin B is a member of the type 1 (stefins) superfamily of cystatins. Cystatin B is encoded by the CSTB gene and functions as an intracellular thiol protease inhibitor regulating the activity of members of the papain family and cathepsins B, H, and L. Cystatin B may also protect cellular components from the effects of proteases that leak from lysosomes. Mutations in the CSTB gene are thought to be the primary defect in patients with Progressive Myoclonus Epilepsy (EPM1).

アプリケーション

Suitable for use as a cysteine-protease inhibitor. Is tested for suitability as an inhibitor of the enzymatic activity of papain.

生物化学的／生理学的作用

Cystatin B was shown to interact with the protein RACK-1, β-spectrin and neurofilament light chain NF-L forming a unique multiprotein complex specifically in the cerebellum, confirming its function in the brain.

再構成

Cystatin B should be reconstituted at 100 μg/mL in steile 25 mM Tris pH 7.5 and 100 mM NaCl. Reconstituted product should be stored in single-use aliquots at -70° C and should be stable for at least 3 months.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable