おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
20 kDa
化学種の反応性
human
濃度
0.5 mg - 1 mg/mL
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... OLR1(4973)
免疫原
Synthetic peptide directed towards the N terminal region of human OLR1
アプリケーション
Anti-OLR1 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.
生物化学的／生理学的作用
Oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1; LOX1) is a receptor for low density lipoprotein (LDL) that belongs to C-type lectin superfamily. It binds, internalizes and degrades oxidized LDL and has a role as scavenger receptor. It may be involved in the regulation of Fas-induced apoptosis. Mutations in OLR1 gene are associated with atherosclerosis and myocardial infarction.
シーケンス
Synthetic peptide located within the following region: QANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQ
物理的形状
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AV45322-100UL:
AV45322-100UG:
最新バージョンのいずれかを選択してください：
Zufeng Ding et al.
Scientific reports, 3, 2091-2091 (2013-06-29)
Here we demonstrate that "concentration polarization" of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and activates LOX-1 dependent autophagy and apoptosis. We also show that ox-LDL concentration polarization occurs on the surface
Angela Pirillo et al.
Mediators of inflammation, 2013, 152786-152786 (2013-08-13)
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on
Ming-Sheng Zhou et al.
American journal of hypertension, 27(6), 873-880 (2014-01-15)
Current treatment for the secondary prevention of cardiovascular diseases frequently involves the prescription of several combination therapies, particularly antihypertensive medications and HMG-CoA reductase inhibitor. We have previously shown that in salt-sensitive hypertension either a statin or the calcium channel blocker
Miyuki Kumano-Kuramochi et al.
Biochemical and biophysical research communications, 434(3), 594-599 (2013-04-16)
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1.
Deenadayalan Bakthavatsalam et al.
FEBS letters, 588(13), 2133-2140 (2014-05-23)
Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a scavenger receptor that binds oxidized low-density lipoprotein (OxLDL) and has a role in atherosclerosis development. The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially through intracellular protein
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