AV40487

抗EIF4G3抗体 ウサギ宿主抗体

affinity isolated antibody

• 別名: 抗真核生物翻訳開始因子4γ, 3抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 57 kDa
• 化学種の反応性: human
• 濃度: 0.5 mg - 1 mg/mL
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_003751
• UniProtアクセッション番号: O43432-2
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EIF4G3(8672)

詳細

詳細

Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is involved in protein translation within the mammalian mRNA ribosome complex. EIF4G3 has been shown to be a target of cytotoxic T lymphocyte (CTL) produced granzyme B (GrB) suggesting that EIF4G3 may be targeted by CTL cells as a mechanism to inhibit the use of host translational machinery by infectious viruses.

特異性

Anti-EIF4G3 polyclonal antibody reacts with human, mouse, rat, and bovine eukaryotic translation initiation factor 4 gamma 3 proteins.

免疫原

Synthetic peptide directed towards the N terminal region of human EIF4G3

アプリケーション

Anti-EIF4G3 polyclonal antibody is used to tag eukaryotic translation initiation factor 4 gamma 3 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of eukaryotic translation initiation factor 4 gamma 3 in the initiation of mRNA translation and as a target of CTL cells during infectious virus assault.

生物化学的／生理学的作用

EIF4G3 is probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5′-terminal secondary structure and recruitment of mRNA to the ribosome. It is thought to be a functional homolog of EIF4G1.

シーケンス

Synthetic peptide located within the following region: TAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIA

物理的形状

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable