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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
aqueous glycerol solution
使用法
10 blots
分子量
antigen 100-140 kDa
化学種の反応性
human
テクニック
western blot: 1:1000 using CAD cells transfected with wild type vs. T668A mutant APP.
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... APP(351)
mouse ... App(11820)
rat ... App(54226)
詳細
Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease.
Rabbit Anti-phospho-APP (pThr668) antibody binds to human APP phosphorylated at Thr668. Mouse, rat and frog APP are 100% homologous.
Rabbit Anti-phospho-APP (pThr668) antibody binds to human APP phosphorylated at Thr668. Mouse, rat and frog APP are 100% homologous.
免疫原
APPのスレオニン688を含む領域に由来する合成リン酸化ペプチド。
アプリケーション
Cultured cortical neurons were immunostained for APP using rabbit anti-phospho-APP (pThr688) antibody.
Rabbit Anti-phospho-APP (pThr668) antibody can be used for western blot applications at a dilution of 1:1,000.
物理的形状
Dulbecco-PBS(Mg2+/Ca2+不含)溶液(pH 7.3, 50%グリセロ-ル, 1.0 mg/mL BSA(IgGおよびプロテア-ゼフリ-), 0.05%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
A9103-BULK:
A9103-VAR:
A9103-1VL-PW:
A9103-1VL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Chun-Yan Wang et al.
Antioxidants & redox signaling, 30(11), 1411-1431 (2018-04-11)
Oxidative stress and neuroinflammation play important roles in the pathology of Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin, is suspected to be an important modulator of oxidative stress and inflammation. However, the underlying mechanism involved
Yoichi Ohshima et al.
The Journal of toxicological sciences, 43(4), 257-266 (2018-04-06)
The increased ratio of longer amyloid-β (Aβ1-42)/shorter amyloid-β (Aβ1-40) peptides, generated from amyloid precursor protein (APP), is known to promote the development of Alzheimer's disease (AD). To investigate the role of smoking in Aβ production, we determined the production of
Roberta Roncarati et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(10), 7102-7107 (2002-05-16)
The beta-amyloid precursor protein (APP) and the Notch receptor undergo intramembranous proteolysis by the Presenilin-dependent gamma-secretase. The cleavage of APP by gamma-secretase releases amyloid-beta peptides, which have been implicated in the pathogenesis of Alzheimer's disease, and the APP intracellular domain
D Goldgaber et al.
Science (New York, N.Y.), 235(4791), 877-880 (1987-02-20)
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced
R E Tanzi et al.
Science (New York, N.Y.), 235(4791), 880-884 (1987-02-20)
The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the beta protein suggests that it derives from a larger protein expressed
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