由来生物
human
品質水準
リコンビナント
expressed in NSO cells
アッセイ
>90% (SDS-PAGE)
フォーム
lyophilized powder
分子量
50-55 kDa by SDS-PAGE (reducing)
calculated mol wt ~37.3 kDa
包装
pkg of 100 μg
保管条件
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
テクニック
cell culture | mammalian: suitable
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... ACVRL1(94)
生物化学的／生理学的作用
ALK-1 is a type I complex of the serine/threonine kinases. Type I and II receptors bind ligands in the TGF-β superfamily. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular domains.
Type I complex of the serine/threonine kinases; bind ligands in the TGF-β superfamily.
物理的形状
凍結乾燥品(0.2 μmフィルターろ過済みPBS溶液)。
アナリシスノート
Can be used as a calibrator for ALK-1 antibodies.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
最新バージョンのいずれかを選択してください：
A Lux et al.
The Journal of biological chemistry, 274(15), 9984-9992 (1999-04-03)
Germ line mutations in one of two distinct genes, endoglin or ALK-1, cause hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized angiodysplasia. Both genes encode endothelial cell receptors for the transforming growth factor beta (TGF-beta) ligand superfamily. Endoglin
P ten Dijke et al.
Oncogene, 8(10), 2879-2887 (1993-10-01)
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity
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