SYNPLE-P024

Reagent-cartridge VHL-PEG4

Synple

• 別名: Synple 2
• MDL番号: MFCD32903606
• UNSPSCコード: 12161503
• NACRES: NA.22

特性

• 品質水準: 100
• パラメーター: up to 0.1 mmol scale

詳細

詳細

Reagent-cartridge VHL-PEG₄ is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a von Hippel-Lindau (VHL) recruiting ligand ((S,R,S)-AHPC) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG₄
E3 ligase target and ligand: von Hippel-Lindau (VHL), (S,R,S)-AHPC
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:

• Reducing agent (supported cyanoborohydride)
• Base (supported triethylamine)
• SCX (for purification)
• Degrader building block linker reagent

Related Cartridges:

• SYNPLE-P001Reagent-cartridge CRBN-PEG₁
• SYNPLE-P002Reagent-cartridge CRBN-PEG₂
• SYNPLE-P003Reagent-cartridge CRBN-PEG₃
• SYNPLE-P004Reagent-cartridge CRBN-PEG₄
• SYNPLE-P005Reagent-cartridge CRBN-PEG₅
• SYNPLE-P021Reagent-cartridge VHL-PEG₁
• SYNPLE-P022Reagent-cartridge VHL-PEG₂
• SYNPLE-P023Reagent-cartridge VHL-PEG₃
• SYNPLE-P025Reagent-cartridge VHL-PEG₅

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform

• Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
• Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
• Safety - all chemicals are contained in the system, minimizing the user′s exposure
• Set-up reaction in less than 5 minutes
• Small footprint
• Plug & Play system - simple installation
• Reaction temperatures from 25 °C - 80 °C
• Cartridges available for many different reactions
• Prefilled with all required reagents
• RFID chip containing optimized reaction protocol

その他情報

An integrated console for capsule-based, automated organic synthesis

法的情報

Product of Synple Chem AG

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable