SMB00969

(E)-10-Hydroxy amitriptyline

≥95% (HPLC)

• 別名: (±)-(E)-5-[3-(ジメチルアミノ)プロピリデン]-10,11-ジヒドロ-5H-ジベンゾ[a,d]シクロヘプテン-10-オール
• 実験式（ヒル表記法）: C₂₀H₂₃NO
• CAS番号: 64520-05-4
• 分子量: 293.40
• MDL番号: MFCD00069200
• UNSPSCコード: 41116107
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• 形状: solid
• テクニック: HPLC: suitable
• 色: white to yellow
• 保管温度: 2-8°C
• SMILES記法: CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
• InChI: 1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
• InChI Key: GHWBJXOKAFHZAI-SFQUDFHCSA-N

詳細

詳細

(E)-10-Hydroxy amitriptyline is a metabolite of Amitriptyline (brand name Elavil), a FDA-approved oral medicine for the treatment of major depressive and anxiety disorders, attention deficit hyperactivity disorder (ADHD), bipolar disorder, as well as migraines and neuropathic pain (fibromyalgia & postherpetic neuralgiapain). Amitriptyline acts mainly on the serotonin transporter (SERT) and moderately on the norepinephrine transporter (NET). Amitriptyline is metabolised by cytochrome P450 enzymes (demethylation by CYP2C19 & CYP3A4) in the liver to Nortriptyline, which also acts as a noradrenaline reuptake inhibitor and thereby potentiates the antidepressant effects of amitriptyline. Amitriptyline and Nortriptyline are subject to metabolisation by hydroxylation (by CYP2D6) and n-oxidation.

アプリケーション

Metabolomics research

生物化学的／生理学的作用

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable