RDD043

アセチルコリンクロリド

≥99% (TLC), free-flowing, Redi-Dri^™

• 別名: ACh
• 化学式: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS番号: 60-31-1
• 分子量: 181.66
• Beilstein: 3571875
• MDL番号: MFCD00011698
• UNSPSCコード: 51151535
• NACRES: NA.25

特性

• 製品種目: Redi-Dri^™
• 品質水準: 100
• アッセイ: ≥99% (TLC)
• 形状: powder
• 品質: free-flowing
• 包装: pkg of 100 g
• 色: white to faint yellow cast
• mp: 146-150 °C (lit.)
• 溶解性: H₂O: 100 mg/mL
• 密度: 1.27 g/cm³
• 保管温度: room temp
• SMILES記法: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI Key: JUGOREOARAHOCO-UHFFFAOYSA-M

詳細

詳細

Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.

アプリケーション

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

生物化学的／生理学的作用

塩化アセチルクロリンを体重1 kg当たり20 mg注入すると、実験的に敗血症を誘発させたマウスの死亡率および血漿中炎症誘発性サイトカインが減少します。コリン作動性抗炎症機序は、おそらくアセチルコリンと単球、マクロファージおよび好中球上のα7nコリン受容体の相互作用に媒介されると思われ、この機序はTNF-α、IL-1β、IL-6などの炎症誘発性サイトカインの濃度を低下させます。

特徴および利点

• Redi-Dri^™ format for Improved Efficiency and Time Savings
• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

注意

吸湿性が高い

その他情報

For additional information on our range of Biochemicals, please complete this form.

法的情報

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable