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Merck

B018

Supelco

WB-4101 hydrochloride

analytical standard

別名:

2-[(2,6-Dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane hydrochloride

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About This Item

実験式(ヒル表記法):
C19H23NO5 · HCl
CAS番号:
分子量:
381.85
EC Number:
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

グレード

analytical standard

品質水準

テクニック

HPLC: suitable
gas chromatography (GC): suitable

フォーマット

neat

SMILES記法

Cl.COc1cccc(OC)c1OCCNCC2COc3ccccc3O2

InChI

1S/C19H23NO5.ClH/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14;/h3-9,14,20H,10-13H2,1-2H3;1H

InChI Key

KAHMEWANVDFFCQ-UHFFFAOYSA-N

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アプリケーション

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)


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Josie R T Silva et al.
The journal of pain : official journal of the American Pain Society, 12(1), 51-60 (2010-06-18)
We evaluated the effectiveness of intrathecal antagonists of α1- (WB4101) and α2- (idazoxan) adrenoceptors and serotonergic (methysergide), opioid (naloxone), muscarinic (atropine), GABA(A) (bicuculline) and GABA(B) (phaclofen) receptors in blocking 2- or 100-Hz electroacupuncture (EA)-induced analgesia (EAIA) in the rat tail-flick
Laura Fumagalli et al.
European journal of medicinal chemistry, 58, 184-191 (2012-11-06)
Unichiral 8-substituted analogues of 2-[(2-(2,6-dimethoxyphenoxy)ethyl)aminomethyl]-1,4-benzodioxane (WB4101) were synthesized and tested for binding affinity at cloned human α(1a)-, α(1b)-and α(1d)-adrenoreceptor (α(1a)-, α(1b)-and α(1d)-AR) and at native rat 5-HT(1A) receptor and for antagonist affinity at α(1A)-, α(1B)-and α(1D)-AR and at α(2A/D)-AR. Among
W-X Yuan et al.
Neuroscience, 158(4), 1616-1624 (2008-12-11)
Activation of the descending noradrenergic system inhibits nociceptive transmission in the spinal cord. Although both alpha(1)- and alpha(2)-adrenoceptors in the spinal cord are involved in the modulation of nociceptive transmission, it is not clear how alpha(1)-adrenoceptors regulate excitatory and inhibitory
K Ichishima et al.
British journal of pharmacology, 161(1), 193-206 (2010-08-20)
Volume-regulated anion channels (VRACs) play an important role in cell-volume regulation. alpha(1)-Adrenoceptor stimulation by phenylephrine (PE) suppressed the hypotonic activation of VRAC current in mouse ventricular cells and regulatory volume decrease (RVD) was also absent in PE-treated cells. We examined
F H F Alves et al.
Neuroscience, 177, 74-83 (2011-01-12)
Dynamic exercise evokes sustained blood pressure and heart rate (HR) increases. Although it is well accepted that there is a CNS mediation of cardiovascular adjustments during dynamic exercise, information on the role of specific CNS structures is still limited. The

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