72345

ニコチンアミド

≥98.5% (HPLC)

• 別名: ナイアシンアミド, ニコチン酸アミド, ビタミンB₃, ビタミンPP, ピリジン-3-カルボン酸アミド
• 実験式（ヒル表記法）: C₆H₆N₂O
• CAS番号: 98-92-0
• 分子量: 122.12
• Beilstein: 383619
• EC Number: 202-713-4
• MDL番号: MFCD00006395
• UNSPSCコード: 12352200
• PubChem Substance ID: 329764008
• NACRES: NA.77

特性

• 由来生物: synthetic
• 品質水準: 200
• アッセイ: ≥98.5% (HPLC)
• フォーム: powder
• 色: colorless to white
• mp: 128-131 °C (lit.); 128-131 °C
• SMILES記法: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• InChI Key: DFPAKSUCGFBDDF-UHFFFAOYSA-N

詳細

詳細

Nicotinamide is synthesized in the liver from nicotinic acid. It is also produced as a result of nicotinamide adenine dinucleotide (NAD⁺) hydrolysis.

アプリケーション

Nicotinamide has been used:

• as a precursor to study its effect on nicotinamide adenine dinucleotide (NAD) concentration in NAD-deficient mammalian mitochondria
• as an inhibitor of sirtuin (SIRT) family of deacetylases in in vitro serine hydroxymethyltransferase 2 (SHMT2) deacetylation assay
• to study its effect on ischemia-reperfusion (I-R) injury-induced cell death in ptenαm/m mice

生物化学的／生理学的作用

ニコチンアミドは、ビタミンB3とPARPインヒビターのアミド誘導体です。

Nicotinamide serves as a precursor for β-nicotinamide adenine dinucleotide (NAD⁺) coenzyme production. It is involved in the synthesis of NAD⁺ phosphate (NADP⁺). It also regulates the mechanism of cell survival and cell death. Fatigue, skin pigmentation, decreased appetite and mouth ulcers are indications of nicotinamide deficiency. Its chronic deficiency can lead to pellagra. Nicotinamide is known to show protective effects on oxidative stress.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): 302.0 °F - closed cup
• 引火点(℃): 150 °C - closed cup
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves