61076

DL-4-ヒドロキシ-2-ケトグルタル酸 リチウム塩

analytical standard

• 別名: 4-ヒドロキシ-2-オキソグルタル酸 リチウム塩
• 実験式（ヒル表記法）: C₅H₆O₆ · xLi⁺
• CAS番号: 1187-99-1
• 分子量: 162.10 (free acid basis)
• Beilstein: 1780096
• UNSPSCコード: 41116107

特性

• グレード: analytical standard
• アッセイ: ≥97.0% (HPLC)
• シェルフライフ: limited shelf life, expiry date on the label
• アプリケーション: clinical testing
• フォーマット: neat
• 保管温度: −20°C
• InChI: 1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)
• InChI Key: WXSKVKPSMAHCSG-UHFFFAOYSA-N

詳細

詳細

DL-4-Hydroxy-2-ketoglutaric acid lithium salt (HOG) is a precursor substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA1), a unique enzyme in the hydroxyproline catabolism pathway. It is reported that the primary hyperoxaluria type 3, which is a recently discovered form of the autosomal recessive disease, results from the mutations in the gene coding for HOGA1.

アプリケーション

DL-4-Hydroxy-2-ketoglutaric acid lithium salt may be used as an analytical reference standard for the determination of the analyte in animal biological samples using ion chromatography coupled to negative electrospray mass spectrometry (IC/ES-MS). This can be used to determine the primary hyperoxalurias PH Type 3 (PH3), caused by the mutations in the mitochondrial enzyme, 4-hydroxy-2-oxoglutarate aldolase (HOGA).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable