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Merck

34088

Supelco

Nitroxinil

VETRANAL®, analytical standard

別名:

4-Hydroxy-3-iodo-5-nitrobenzonitrile, Nitroxynil

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About This Item

実験式(ヒル表記法):
C7H3IN2O3
CAS番号:
分子量:
290.01
EC Number:
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

グレード

analytical standard

品質水準

製品種目

VETRANAL®

シェルフライフ

limited shelf life, expiry date on the label

テクニック

HPLC: suitable
gas chromatography (GC): suitable

アプリケーション

forensics and toxicology
pharmaceutical (small molecule)

フォーマット

neat

SMILES記法

Oc1c(I)cc(cc1[N+]([O-])=O)C#N

InChI

1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H

InChI Key

SGKGVABHDAQAJO-UHFFFAOYSA-N

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詳細

Nitroxinil is an anthelmintic agent, which is also an antiparasite. It is highly effective against Fasciola species and its mode of action involves uncoupling the oxidative phosphorylation in liver flukes and also reduces spermatogenesis in surviving flukes, resulting in fewer fertile eggs.

アプリケーション

Nitroxinil may be used as a reference standard in the determination of nitroxinil in veterinary active pharmaceutical ingredient manufacturing and bovine kidney using reversed-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法的情報

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

ピクトグラム

Skull and crossbonesEnvironment

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

ターゲットの組織

Respiratory system

保管分類コード

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

毒物及び劇物取締法

劇物

労働安全衛生法名称等を表示すべき危険物及び有害物

名称等を表示すべき危険物及び有害物

労働安全衛生法名称等を通知すべき危険物及び有害物

名称等を通知すべき危険物及び有害物

Jan Code

34088-100MG:4548173907130
34088-BULK:
34088-VAR:


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試験成績書(COA)

Lot/Batch Number

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W J Blanchflower et al.
The Analyst, 114(9), 1013-1015 (1989-09-01)
A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction step. Any nitroxynil present was separated from interfering compounds by high-performance
Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.
Caldow M, et al.
Journal of Chromatography A, 1216(46), 8200-8205 (2009)
C Boulard et al.
Veterinary research, 26(4), 249-255 (1995-01-01)
The responses of cattle infected with Fasciola hepatica to treatment with nitroxynil or closantel were monitored by faecal egg counts and by ELISA assay of anti-fluke antibodies. A first trial with experimentally infected heifers showed an increase in anti-fluke antibody
R Maffei Facino et al.
Arzneimittel-Forschung, 43(4), 455-460 (1993-04-01)
Liver fluke infection (Fasciola hepatica) depresses the drug-metabolizing capacity of the hepatic mixed function oxidase (MFO) and glucuronosyltransferase (GT) enzyme systems, throughout a free radicals mediated lipid peroxidation process. Glutathione (GSH, CAS 70-18-8) administered chronically (100 mg/kg i.p. once daily
M Alvinerie et al.
Journal of veterinary pharmacology and therapeutics, 14(2), 170-173 (1991-06-01)
The binding of nitroxynil to total plasma proteins of cows, sheep and rabbits was characterized using equilibrium dialysis. The data indicate clearly that nitroxynil was highly (97-98%) bound to plasma protein of each animal. This linear binding would be due

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