MABN453

Anti-CHRDL1 Antibody, clone 10C9.3

clone 10C9.3, from mouse

• 別名: Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 10C9.3, monoclonal
• 化学種の反応性: human, rat
• テクニック: immunohistochemistry: suitable; western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001137453
• UniProtアクセッション番号: Q9BU40
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CHRDL1(91851)

詳細

詳細

Chordin-like protein 1 (CHRDL1) is an important secreted developmental mediator protein expressed in developing cornea, retina, brain, cerebellum and neocortex and developing bone. CHRDL1 in the nervous system alters the fate commitment of neural stem cells from gliogenesis to neurogenesis and contributes to neuronal differentiation of neural stem cells in the brain by the preventing the adoption of a glial fate. CHRDL1 also plays a critical role in dorsventral axis formation and regulates the action of BMP4 and preventing it from interacting with its receptors. In the developing eye CHRDL1 regulates retinal angiogenesis and the development of the anterior segment of the eye. Mutations in CHRDL1 are associated with various eye disorders and in particular one named Megalocornea 1, an X-linked developmental disease.

免疫原

KLH-conjugated linear peptide corresponding to human CHRDL1.

アプリケーション

Research Category
ニューロサイエンス

This Anti-CHRDL1 Antibody, clone 10C9.3 is validated for use in Western Blotting and Immunohistochemistry for the detection of CHRDL1.

品質

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CHRDL1 in 200 µg of rat brain tissue lysate.

ターゲットの説明

~65 kDa observed. The calculated molecular weight of this protein is 50 kDa, but can be observed at ~65 kDa due to high glycosylation.

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected CHRDL1 in 200 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CHRDL1 in human retina, human cerebellum, rat cerebellum, and rat cerebral cortex tissue.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable