MABN358

Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

clone 4A6.3, from mouse

• 別名: Thymosin beta-15A, NB thymosin beta, Thymosin-like protein 8
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 4A6.3, monoclonal
• 交差性: human
• テクニック: immunohistochemistry: suitable (paraffin)
• アイソタイプ: IgMκ
• NCBIアクセッション番号: NP_068832
• UniProtアクセッション番号: P0CG34
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TMSB15A(11013)

詳細

詳細

TMSB15A protein is a key regulator of the cytoskeleton organization and polymerization, and it thus plays a role in cell migration, proliferation and cancer. TMSB15A does this because TMSB15A binds to and sequesters actin monomers and limits action polymerization. TMSB15A is differentially expressed in many tissues and cancer cell lines. Because of differential expression in certain cancers, for instance in triple negative breast cancer but not colon cancer, TMSB15A is being examined as a histochemical marker for measuring the effectiveness of cancer therapy on cancer. TMSB15A is also important in the nervous system and brain diseases. Notably, TMSB15A expression is increased upon brain stress and surprisingly TMSB15A localization differs depending upon the type of stress used and neuronal cell type. Because of its interaction with actin, TMSB15A is localized to the cytoplasm most of time, however, in the brain and when cells are placed under various stresses, TMSB15A can be translocated to the brain to perform yet unknown functions as well.

免疫原

KLH-conjugated linear peptide corresponding to Human TMSB15A.

アプリケーション

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human thalamic and human brain cancer tissues.

This Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 is validated for use in Immunohistochemistry (Paraffin) for the detection of NB thymosin beta (TMSB15A).

品質

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human cerebral cortex tissue

ターゲットの説明

5 kDa calculated

物理的形状

Format: Purified

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable