MABF2745

Anti-CD200R Antibody, clone OX-108

• 別名: CD200 cell surface glycoprotein receptor, CD200R, CRTR2, Cell surface glycoprotein CD200 receptor 1, Cell surface glycoprotein OX2 receptor 1, MOX2R, OX2R, UNQ2522/PRO6015
• UNSPSCコード: 12352203

特性

• 由来生物: mouse
• 品質水準: 200
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: OX-108, monoclonal
• 分子量: calculated mol wt 36.60 kDa
• 精製方法: using protein G
• 化学種の反応性: human
• 包装: antibody small pack of 100
• テクニック: flow cytometry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; inhibition assay: suitable; surface plasmon resonance (SPR): suitable
• アイソタイプ: IgG1κ
• エピトープ配列: Extracellular domain
• タンパク質IDアクセッション番号: NP_620161
• UniProtアクセッション番号: Q8TD46
• 保管温度: -10 to -25°C
• 遺伝子情報: human ... CD200R1(131450)

詳細

特異性

Clone OX-108 is a mouse monoclonal antibody that detects CD200R. It targets an epitope within the extracellular domain.

免疫原

Full-length, recombinant human CD200R.

アプリケーション

Quality Control Testing

Evaluated by Flow Cytometry with human peripheral blood mononuclear cells (PBMCs).

Flow Cytometry Analysis: 1.0 µg from a representative lot detected CD200R in one million human peripheral blood mononuclear cells (PBMCs).

Tested Applications

Surface Plasmon Resonance: A representative lot detected CD200R in surface plasmon resonance application (Hatherley, D., et al. (2004). Eur J Immunol. 34(6):1688-94).

Immunohistochemistry Application: A representative lot detected CD200R in immunohistochemistry application (Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).

Inhibition: A representative lot blocked ligand-receptor interactions in protein microarray application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).

Flow Cytometry Analysis: A representative lot detected CD200R in flow cytometry application (Wright, G.J., et al. (2003). J Immunol. 171(6):3034-46; Foster-Cuevas, M., et al. (2004). J Virol. 78(14):7667-76; Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).

Immunofluorescence Analysis: A representative lot detected CD200R in immunofluorescence application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.

ターゲットの説明

Cell surface glycoprotein CD200 receptor 1 (UniProt: Q8TD46; also known as CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1) is encoded by the CD200R1 (also known as CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015) gene (Gene ID: 131450) in human. CD200R is an inhibitory receptor that plays a crucial role in the regulation of immune responses. It is primarily involved in maintaining immune homeostasis by delivering inhibitory signals that downregulate inflammatory responses and prevent overactivation of the immune system. Upon binding with its ligand, CD200, CD200R transduces signals that inhibit the activation of macrophages, dendritic cells, and other immune cells, thereby promoting tolerance and preventing autoimmune reactions. CD200R is expressed on various immune cells, including macrophages, dendritic cells, neutrophils, and certain subsets of T cells and B cells. It is also found on some non-immune cells, such as neurons and endothelial cells. The expression of CD200R1 is generally upregulated in response to inflammatory stimuli and during certain stages of immune cell differentiation. CD200R is implicated in various autoimmune diseases, cancer, infectious and neurodegenerative diseases.

物理的形状

Purified mouse monoclonal antibody IgG1 in PBS without azide.

再構成

0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

保管および安定性

Store at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable