MABC287

Anti-PXR Antibody, clone 1F10.1

clone 1F10.1, from mouse

• 別名: Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR, PXR
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 1F10.1, monoclonal
• 交差性: human
• 交差性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology), gorilla (based on 100% sequence homology)
• テクニック: western blot: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_003880
• UniProtアクセッション番号: O75469
• 輸送温度: dry ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NR1I2(8856)

詳細

詳細

Nuclear receptor subfamily 1 group I member 2 (UniProt O75469; also known as Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X nuclear receptor, Steroid and xenobiotic receptor, SXR) is encoded by the NR1I2 (also known as BXR, PAR, PRR, PXR, SAR, SXR, ONR1) gene (Gene ID 8856) in human. Pregnane X receptor (PXR) is a nuclear receptor that displays similarity to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, a P450 enzyme involved in drug metabolism.

特異性

Epitope is present in all 7 alternative spliced isoforms (isoform 1A/PRR1-A, 1B/PRR1-B, 1C/PRR1-C, 2A/PRR2-A, 2B/PRR2-V, 2C/PRR2-C, and isoform 3).

免疫原

KLH-conjugated linear peptide corresponding to human PXR.

アプリケーション

Detect PXR using this Anti-PXR Antibody, clone 1F10.1 validated for use in Western Blotting.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected PXR in 10 µg of human liver tissue lysate.

品質

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PXR in 10 µg of human colon tissue lysate.

ターゲットの説明

~53 kDa observed. Uniprot describes 7 isoforms produced by alternative splicing ranging from ~40 kDa-54 kDa

物理的形状

Format: Purified

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable