MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

• 別名: EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 689, monoclonal
• 交差性: mouse
• 交差性（ホモロジーによる予測）: chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• テクニック: ELISA: suitable; immunohistochemistry: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_115823
• UniProtアクセッション番号: Q75N90
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EFEMP1(2202)

詳細

詳細

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

特異性

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

免疫原

Recombinant protein corresponding to human Fibrillin 3.

アプリケーション

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

品質

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

ターゲットの説明

~ 350 kDa calculated

物理的形状

Format: Purified

アナリシスノート

Control
Mouse skin tissue

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable