ABS457

Anti-ASAH2 Antibody

from rabbit, purified by affinity chromatography

• 別名: N-acylsphingosine amidohydrolase, Non-lysosomal ceramidase 2, HNAC1, Neutral ceramidase, Acylsphingosine deacylase 2, ASAH2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: western blot: suitable
• UniProtアクセッション番号: Q9NR71
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ASAH2(56624)

詳細

詳細

N-acylsphingosine amidohydrolase 2 (ASAH2), also known as neutral ceramidase (N-CDase, NCDase), is a key regulator of sphingolipid signaling metabolites. ASAH2 is known to hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Additionally, ASAH2 is suggested to act as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. ASAH2 is also suggested to be involved in the digestion of dietary sphingolipids in intestine tract. In this role, ASAH2 is implied to act as a key enzyme for the catabolism of dietary sphingolipids and consequently, regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. ASAH2 is expressed primarily in the intestine. It is also expressed with higher levels in kidney, skeletal muscle and heart.

免疫原

KLH-conjugated linear peptide corresponding to human ASAH2.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
発生シグナル伝達

Anti-ASAH2 Antibody is a highly specific rabbit polyclonal antibody, that targets ASAH2 & has been tested in western blotting.

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected ASAH2 in 15 µg of HEK293 cell lysate.

ターゲットの説明

~70 kDa observed. Uniprot describes 2 isoforms at ~82 kDa and ~86 kDa Uncharacterized bands may appear in some lysate(s).

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
HEK293 cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable