おすすめの製品
由来生物
rabbit
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
mouse
テクニック
immunohistochemistry: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Rfx6(320995)
詳細
Rfx6 (regulatory factor X 6) is a winged-helix transcription factor that is essential for development and seems to be located exclusively in the pancreatic islets. It has been associated with endoderm development, specifically, and the differentiation of islet cells. Since insulin production happens in the beta-cells of pancreatic islets, Rfx6 may be used clinically to treat diabetes. Recently, Rfx6 function has been found to change over time and gets restricted to endocrine cells at later stages. Mitchell-Riley syndrome is thought to stem from a Rfx6 mutation.
免疫原
GST-tagged recombinant protein corresponding to mouse Rfx6.
アプリケーション
Research Category
幹細胞研究
幹細胞研究
Research Sub Category
転写因子
転写因子
Anti-Rfx6 Antibody is a Rabbit Polyclonal Antibody for detection of Rfx6 also known as DNA-binding protein RFX6, Regulatory factor X 6 & has been validated in IHC.
品質
Evaluated by Immunohistochemistry in mouse embryo pancreas tissue.
Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Rfx6 in mouse embryo pancreas tissue.
Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Rfx6 in mouse embryo pancreas tissue.
ターゲットの説明
102 kDa calculated. Additional isoforms at 59 and 73 kDa have also been reported.
物理的形状
Unpurified
Rabbit polyclonal serum containing 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
アナリシスノート
Control
Mouse embryo pancreas tissue
Mouse embryo pancreas tissue
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ABD28:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Jing Lu et al.
Journal of molecular endocrinology, 66(2), 129-140 (2020-12-23)
RFX6 transcription factor is believed to play a central role in directing cell development of insulin-producing pancreatic islet. RFX6 homozygous mutations cause syndromic neonatal diabetes with hypoplastic pancreas. However, RFX6 heterozygous mutations cause maturity-onset diabetes of the young (MODY) with
Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.
Suzuki, K; Harada, N; Yamane, S; Nakamura, Y; Sasaki, K; Nasteska, D; Joo, E; Shibue et al.
The Journal of Biological Chemistry null
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）