ABD133

Anti-ACVR1B Antibody

from rabbit, purified by affinity chromatography

• 別名: Activin A receptor type IB, Activin receptor-like kinase 4, Activin receptor type 1B precursor, ACTR-IB, ACVRLK4, ALK4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: western blot: suitable
• UniProtアクセッション番号: P36896
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ACVR1B(91)

詳細

詳細

Activin receptor type-1B (ACVR1B) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. ACVR1B is known to form activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Within this receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors (including ACVR1B) act as downstream transducers of activin signals. Activins play role in many physiological and pathological processes including neuronal differentiation and neuronal survival, wound healing, extracellular matrix production, hair follicle development and cycling, FSH production, immunosuppression and carcinogenesis. ACVR1B is expressed highly in systemic sclerosis patient fibroblasts which suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. ACVR1B is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of human ACVR1B.

アプリケーション

Research Category
幹細胞研究

Research Sub Category
多能性及び初期分化

Anti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting.

品質

Evaluated by Western Blotting/Peptide Inhibition Assay in human kidney tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate.

ターゲットの説明

~70 kDa observed. Uniprot describes 5 isoforms ranging between ~52 kDa and ~62 kDa

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Human kidney tissue lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable