ABC830

Anti-SEC62 Antibody

from rabbit, purified by affinity chromatography

• 別名: Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: polyclonal
• application: IHC; WB
• 化学種の反応性: mouse, rat
• テクニック: immunohistochemistry: suitable; western blot: suitable

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse, rat
• テクニック: immunohistochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q99442
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SEC62(7095)

詳細

詳細

Translocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.

特異性

This antibody is predicted to not cross-react with other SEC proteins.

免疫原

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected SEC62 in mouse brain tissue.

品質

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 0.5 μg/mL of this antibody detected SEC62 in rat brain tissue lysate.

ターゲットの説明

~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable