由来生物
rabbit
品質水準
抗体製品の状態
affinity purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
polyclonal
精製方法
affinity chromatography
化学種の反応性
mouse
メーカー／製品名
Chemicon®
テクニック
ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Ucp2(22228)
特異性
Uncoupling Protein 2 (UCP2), mouse. Mouse UCP2 is a 309 amino acid mitochondrial uncoupling protein (Fleury et al. 1997). It is only 59% homologous with UCP1 found in brown adipose tissues. Mouse UCP2 (chromosome 7) has approximately 95% homology with human UCP2 located on chromosome 11 (Fleury et al. 1997). UCP2 has wide tissue distribution in mouse tissues (brain, kidney, liver, brown adipose tissue, heart, and muscle). UCP2 may play a critical role in energy balance, body weight, and thermoregulation (Fleury et al. 1997; Flier & Lowell 1997).
SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology in rat, 86% homology in human, porcine, canine and bovine.
SPECIES REACTIVITIES: The antibody has not yet been tested for cross-reactivity to other species. The sequence used for immunization shows 100% homology in rat, 86% homology in human, porcine, canine and bovine.
免疫原
14 aa peptide sequence near the C-terminus of the mouse UCP2 (Fleury et al. 1997). The peptide has no significant homology with UCP1 or UCP3 (Boss et al. 1997). This peptide is available for blocking as catalog number AG788.
アプリケーション
Research Category
代謝
代謝
Research Sub Category
イオン及び輸送チャネル
イオン及び輸送チャネル
Anti-Uncoupling Protein 2 Antibody is an antibody against Uncoupling Protein 2 for use in ELISA & WB.
Western Blotting: 1-10 μg/mL using Chemiluminescence technique.
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well.
Optimal working dilutions must be determined by end user.
ELISA: 1:10,000-1:100,000; using 50-100 ng UCP2 control peptide/well.
Optimal working dilutions must be determined by end user.
物理的形状
Affinity purified immunoglobulin. Liquid in PBS, pH 7.4 with 0.1% BSA as stabilizer and 0.02% sodium merthiolate.
保管および安定性
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Obesity research springs a proton leak.
J S Flier et al.
Nature genetics, 15(3), 223-224 (1997-03-01)
C Fleury et al.
Nature genetics, 15(3), 269-272 (1997-03-01)
A mitochondrial protein called uncoupling protein (UCP1) plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial membrane in brown adipose tissue, without coupling
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