由来生物
rabbit
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
精製方法
affinity chromatography
化学種の反応性
human, mouse
テクニック
immunocytochemistry: suitable
western blot: suitable
アイソタイプ
IgG
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MTDH(92140)
詳細
Metadherin is a type 2 transmembrane protein who′s overexpression was first described in breast cancers. It plays an important role in the metastasis of breast cancers into the lungs as a secondary site of development. Antibodies reactive to the lung-homing domain of metadherin and siRNA-mediated knockdown of metadherin expression in breast cancer cells inhibited experimental lung metastasis, indicating that tumor cell metadherin mediates localization at the metastatic site (Brown, 2009).
特異性
The antibody recognizes Metadherin at and around the homing domain.
免疫原
Epitope: Homing domain
Recombinant GST-tagged proteins corresponding at or around the lung homing domain of mouse Metadherin.
アプリケーション
Research Category
細胞骨格
細胞骨格
Research Sub Category
接着分子（CAM）
接着分子（CAM）
Anti-Metadherin Antibody is an antibody against Metadherin for use in WB & IC.
Western blot Analysis: 0.25 µg/ml of this antibody detected Metadherin in 10 µg of HEK293, HepG2, and Jurkat cell lysates.
Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Metadherin in NIH/3T3 and HeLa cells.
Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Metadherin in NIH/3T3 and HeLa cells.
品質
Evaluated by Western blot in HeLa cell lysate.
Western blot Analysis: 0.25 µg/ml of this antibody detected Metadherin in 10 µg of HeLa cell lysate.
Western blot Analysis: 0.25 µg/ml of this antibody detected Metadherin in 10 µg of HeLa cell lysate.
ターゲットの説明
~ 75 kDa
物理的形状
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
アナリシスノート
Control
HeLa cell lysate
HeLa cell lysate
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AB2989:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Sung-Suk Suh et al.
PLoS genetics, 10(10), e1004652-e1004652 (2014-10-24)
Metastasis is the principal cause of cancer death and occurs through multiple, complex processes that involve the concerted action of many genes. A number of studies have indicated that the Fragile Histidine Triad (FHIT) gene product, FHIT, functions as a
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