AB16530

Anti-BAFF Antibody, CT

Chemicon^®, from rabbit

• 別名: TALL-1, THANK, BLyS
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: rat, human, mouse
• メーカー／製品名: Chemicon^®
• テクニック: western blot: suitable
• NCBIアクセッション番号: NM_006573.3
• UniProtアクセッション番号: Q9Y275
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TNFSF13B(10673) ; mouse ... Tnfsf13B(24099) ; rat ... Tnfsf13B(498666)

詳細

特異性

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BlyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal kinase) (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999). BAFF/BlyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion (Moore et al. 1999; Schneider et al. 1999). Two receptors for BAFF were recently identified and designated TACI and BCMA (Gross et al. 2000). BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases (Gross et al. 2000; Khare et al. 2000). Like TNFalpha and TRAIL, THANK was shown to activate NF-kB and c-jun N-terminal kinase (JNK) and to induce apoptosis (Mukhopadhyay et al. 1999).

免疫原

Epitope: C-terminus

Rabbit anti-BAFF (C-term) polyclonal antibody was raised against a peptide corresponding to amino acids 254 to 269 of human BAFF (Moore et al. 1999; Schneider et al. 1999; Shu et al. 1999; Mukhopadhyay et al. 1999).

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
BCL2とその阻害

Anti-BAFF Antibody, C-terminus detects level of BAFF & has been published & validated for use in WB.

Western blot: 0.25 to 1 μg/mL.

Optimal working dilutions must be determined by end user.

物理的形状

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

保管および安定性

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable