AB15080

Anti-Frataxin Antibody

from rabbit

• 別名: Anti-CyaY, Anti-FA, Anti-FARR, Anti-FRDA, Anti-X25
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: polyclonal
• application: WB
• 化学種の反応性: rat, mouse, human
• テクニック: western blot: suitable

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: rat, mouse, human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_000135
• UniProtアクセッション番号: Q16595
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FXN(2395) ; mouse ... Fxn(14297) ; rat ... Fxn(499335)

詳細

詳細

Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).

特異性

Cat. # AB15080 recognizes Frataxin.

免疫原

Epitope: mature chain

GST-tagged Frataxin corresponding to mature chain.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
神経変性疾患

This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.

品質

Routinely evaluated by Western Blot on Human heart lysates.

Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate

ターゲットの説明

Approx. 18 kDa

物理的形状

GST-depleted sera

Format: Purified

Rabbit polyclonal serum in buffer containing 0.05% NaN3.

保管および安定性

Stable for 1 year at -20ºC from date of receipt.

アナリシスノート

Control
Human heart lysate.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable