8.55074

Weinreb AM resin

Novabiochem^®

• 別名: N-Fmoc- N-methoxy-β-alanine AM resin
• UNSPSCコード: 12352203

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• 形状: beads
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 保管温度: 2-30°C

詳細

詳細

This support is useful for the production of peptide aldehydes and other carboxaldehydes. Following removal of the Fmoc group with 20% piperidine in DMF, acylation of the resin-bound methoxylamine is best effected using DIPCDI/HOAt or HATU/DIPEA activation. This results in formation of a supported Weinreb-type amide which can be either reduced to an aldehyde with LiAlH4 ^[1,2] or cleaved with Grignard reagents to give ketones ^[2,3].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

関連事項

Replaces: 01-64-0153

アナリシスノート

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable