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品質水準
製品種目
NovaSyn® TG
Novabiochem®
形状
beads
反応適合性
reaction type: Fmoc solid-phase peptide synthesis
メーカー／製品名
Novabiochem®
アプリケーション
peptide synthesis
官能基
alcohol
保管温度
2-30°C
詳細
NovaSynTG hydroxy resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol, in which the ends of the PEG chains have been functionalized with hydroxyl groups. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling across a wide range of solvents from toluene to water [1,2,3], making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This support has been used for the solid phase immobilization of carboxylic acids [4,5,6,7,8,9], with cleavage by saponification with dilute aq. NaOH.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
関連事項
Replaces: 01-64-0096
アナリシスノート
Color (visual): white to amber to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
法的情報
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
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