8.52109

Fmoc-Gly-(Dmb)Gly-OH

≥98% (TLC), for peptide synthesis, Novabiochem^®

• 別名: Fmoc-Gly-(Dmb)Gly-OH, N-α-Fmoc-L-glycyl-N-α-(2, 4-dimethoxybenzyl)-glycine
• 実験式（ヒル表記法）: C₂₈H₂₈N₂O₇
• CAS番号: 848861-65-4
• 分子量: 504.53
• MDL番号: MFCD08064315
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 製品名: Fmoc-Gly-(Dmb)Gly-OH, Novabiochem^®
• 品質水準: 200
• 製品種目: Novabiochem^®
• アッセイ: ≥90.0% (acidimetric); ≥95.0% (HPLC); ≥98% (TLC)
• フォーム: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 官能基: Fmoc
• 保管温度: 2-8°C
• SMILES記法: N(Cc4c(cc(cc4)OC)OC)(CC(=O)O)C(=O)CNC(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C28H28N2O7/c1-35-19-12-11-18(25(13-19)36-2)15-30(16-27(32)33)26(31)14-29-28(34)37-17-24-22-9-5-3-7-20(22)21-8-4-6-10-23(21)24/h3-13,24H,14-17H2,1-2H3,(H,29,34)(H,32,33)
• InChI Key: NJUCBQMDTSVIGD-UHFFFAOYSA-N

詳細

詳細

The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin ^[1]. Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP^®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

^[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.

関連事項

Replaces: 04-12-1266

アナリシスノート

Color (visual): white to slight yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable