681667

Wnt Agonist II, SKL2001

The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications.

• 別名: Wnt Agonist II, SKL2001, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
• 実験式（ヒル表記法）: C₁₄H₁₄N₄O₃
• CAS番号: 909089-13-0
• 分子量: 286.29
• MDL番号: MFCD14733081
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: pink-red
• 溶解性: DMSO: 100 mg/mL, clear, red
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=NC=C3
• InChI: 1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
• InChI Key: PQXINDBPUDNMPE-UHFFFAOYSA-N

詳細

詳細

A cell-permeable imidazolyl-isoxazolamide compound that upregulates β-catenin-regulated transcription (CRT; Effective conc. 10 - 40 µM) by blocking/disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser³³/Ser³⁷/Thr⁴¹/Ser⁴⁵) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Wnt pathway activation by SKL2001 is shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).

A cell-permeable imidazolyl-isoxazolamide that upregulates β-catenin-regulated transcription (CRT; 10 - 40 µM) by disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser³³/Ser³⁷/Thr⁴¹/Ser⁴⁵) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Gwak, J., et al. 2012. Cell Res.22, 237.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable